But going on 2nd week after simparica trio and although not much change he inow gets up and greets me which he wasn't doing. Eight hours later and she has terrible diarrhea and vomiting, now she is not eating. We are closely monitoring him. If you havent already done so, please call the simparica trio phone number and report your dogs symptoms. , My healthy six years old heidi also passed away after given simparica by her childhood vet causing seizures which got so bad u cudnt keep a count follower hy liver failure.dont give ny tick fleas medication orally. He had an MRI and it came out good. This is happening now and she is still nowhere near 100% but I am hopeful that she will eventually fully recover. My 10 year old Standard Poodle had one dose of Simparica and had seizures two weeks later, which was yesterday. I can not find any information on a delayed reaction AND my Vet just discredits that its the Simparica because my dog goes to Daycare and could be exposed to other mystery things. Can blocking GABA receptors also cause inflammation of spine? AVOID THIS PILL! The simparica pushed his body into an Addison's Crisis - his body was literally shutting down. I bought chicken last night he ate some of that . This content shouldnt take the place of advice by your vet. My 5 year old Fox Hound isnow drinking lots of water and urinating in the house! Just our own personal experience but I won't get burned again! It is Now 3 pm and Lily is on her way to the animal hospital and most likely going to have to spend the night, we will flush her with iv and hope It helps Flush It out Of her system. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. Just wondering? My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. Her heartbeat was more of a vibration than a beat and the vet wanted her to see a cardiologist. I hope we get to the bottom of it as this is not fun. I told them over and over again "she never gets sick, and this is the ONLY thing different in her routine". This morning I caught him chewing the end of his tail and eating his fur. I gave my morkie poo simparica trio from age 4 months until age 1 on advice of his vet. A couple of weeks later she had lost weight from not eating. My other two dogs had a little loose stool but nothing else. I just cross my fingers every day that she will get better after this is out of her system. She had a beautiful coat of fur. From classic to celeb-inspired and funny to food-based, this list of cute cat names is sure to inspire your naming adventures. I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. Monday morning - 11 days after he is like a zombie - all motions are almost mechanical and when I talk to him it takes him a long while to react. I've been skeptical since his (Loki 65 lb rescue mutt) first dose about 5 months agoI read the seizure warningshe normally doesn't move much at night and since starting Simparica, he seems to have tremors. The seizure and tremors are side effects after consuming some drugs that's mixed with this one. Almost $4k in medical labs, hospital, ultrasound etc no answers. I won't sleep until we all get the justice for our babies that don't have voices of their own. He is a 6 month old Bloodhound so they are always hyper. After about 35 days he was back to normal. It has been five days and the diarrhea started on day 2. I gave this to my 2 rescue frenchies.. 2 days after 1 of them threw up..she didn't want to eat and started stumbling..leaning to the right, I thought vestibular but that is old dogs disease..I took her to the vet, did bloodwork that came back ok..she is on steroids and anti nausea meds..she is eating now..drinking alot and acts like she is deaf..she is only 6 yrs old. The ONLY thing that could cause such a huge change in behavior and personality had to be giving him the Simparico Trio the previous week. i know this med did this to her , she was on for a year and half , i should never ever have listened to the vet and went with my gut, but again they assured me since she was healthy be very rare she would have side effects smdh and plus been in contract with the makers of this horrible medication they all should be ashamed of themselves!!!!!!!!!!! She had been on the Seresto collar and Tri-Heart for 8 years with no issues. Then things got progressively worse. Sold as 1 Month, 3 Month or 6 Month Supply for the following dog weights : 2.8-5.5 lbs, 5.5-11 lbs, 11-22 lbs, 22-44 lbs, 44-88 lbs, 88-132 lbs. He is still not himself, walks very slowly and is definitely not feeling his best. Use with caution in dogs with a history of seizures. I am very worried I called the vet they said oops sorry they made a mistake. If not, we had some success with symptom management using Prednisone. Banfield Hospital pushed" Simparica Trio" on our 16 year old Toy Poodle which caused a neurological disorder of sundowner to the point of him having two days straight of constant seizures, repetitive pacing and extreme agitation. My 8 month old labradoodle has had 2 doses of Simparico Trio. Im praying over him too . We may also give additional medications to keep fleas, ticks, and common intestinal parasites away. My poor puppy has to go under anesthesia on top of. My dog is on a "health care plan" with my vet. She was due to get the next dosage this week and i am choosing not to give it to her with the hopes that it will be out of her system and her Liver levels will go down. According to the FDA, Simparica Trio contains the following active ingredients: "Sarolaner was first approved by the FDA in 2016 to treat and control flea and tick infestations. They are also drinking more than normal. Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrheaboth symptoms related to Fido's digestive tract, rather than his nervous system. So the next day was Saturday , me & my husband got up early . I lost my girl 2 days after taking Simparica. They did an ultrasound (2 of them), X-rays, blood test, gave fluids, did another ultrasound (looking for a master fluid that keeps popping up and going away between her stomach cavity & spinal cord. I check this thread regularly and Im sooo grateful to all who wrote. Generally, they may instruct you to administer it immediately when you remember and resume monthly dosing. On the first day he woke up and peed in my bedroom floor. The Simparica chewable is a poor choice for dogs with a history of prior seizures. Im not sure if the simperica is the cause. The more we complain the more chance we have of saving other dogs. She nearly died. I originally wanted to get Nexgard, but for some odd reason, when I had went to my vet to pick it up, instead they gave me this. We are currently going through this with our nine year old dachshund. Overly anxious. How is your cockapoo doing now? I wish I would have researched this before giving it to my puppy who is only 10 weeks, he has the same symptoms . The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. Pyrantel Pamoate was first approved in 1977 for the treatment and . They want to test him for the MDR gene, put him on fluids and I have to take him in tomorrow for more fluids but he is not improving. As I said, the first was a week after taking it, then the 2nd and third seizure happened at day 29. If these symptoms appear on your pet, do not worry, it is normal after taking a dose of Simparica. All oral tick meds are a risk. They can also have major side effects. Just after the 4th dose he started to collapse at his feeding dishes on the floor, next we raised dishes and he did ok for being shaky but continued to decline to the point where he could not use dishes , and now cant eat or drink. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. Today March 20 (8 week old) I get a message saying the puppy ate one of these pills that was for the bigger dog she already owned. It is like night and day compared to her regular personality or demeanor. Very dissapointed with my vet for not informing me of the risk this has on my dog. the vet suggested it because she has hookworm..This morning she was shaking and no appetite..After reading all these comments I am scared to death for her. Neurologist doesnt seem to really know if the effects are long term or not. I am interested in the petition and the company's response. I have a vet appointment tomorrow to figure it out. Im certain that its the simparica. Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. Do you think that Simparica could cause excessive licking by my dog. Wow. My chihuahua was given this three weeks back, I actually requested I kept my old treatment but they assured me it was safe and good. Im convinced it was caused by this drug. Im wondering if anyone else has seen these types of symptoms. Another call to vet asking for an appt - seems like an an emergency now? I wish I could get this out of her system now. He was lethargic & laying in his crate alot . Simparica Trio is a veterinary medicine used to treat dogs with flea or tick infestations and roundworm or hookworm infections in the gut. The risk and consequences of tick paralysis are much higher than the risk of side effects. I am sorry you are going through this! 1 dose of this Simperica Trio and he is completely different and cant hold his pee. None of our pets did they were healthy. She is lethargic, unsteady on her feet, doesnt bark at all, showing signs of dimentia. Call the FDA. And how long for this sheet to get out of the dogs system??? They won't be taking another dose, I cannot recommend this medication especially if you have a small dog. . Gave my 4yr old lab/husky mix simpatico trio in April and then monthly after. Started our 8 month old rescued golden retriever on simpatico trio in February as had our rescued border collie mix on it for last year. So sorry to hear, and good for you in recognizing the problem! Simparica Trio works to prevent heartworm disease, treat and prevent flea infestations, treat and control tick infestations, and treat and control roundworms and hookworms. Puppy Simparico Trio for the first time 2 days ago. We just gave the first does to our 11 week old Sheepadoodle puppy yesterday. Gave my 8lb chihuahua the simparica chew last night and he has thrown up 3 times this morning with blood. A dog fence is an important detail to consider when adopting a pet for the first time or moving your dog to a new home. But this month we are at day 7 and I expect the diarrhea it to continue. Everything else in his environment, world has remained the same. Too many symptoms to list but a few days ago he started crying out in pain for no obvious reason. I am so upset - I gave it to him last week and he had an accident in the house. No more of this poison for him. Two weeks after I made the post above our girl started having seizures and we had to put her down. I knew it was bad from the onset but the vet said I can't take a chance on him getting heartworms because the mosquitos are so bad not to mention fleas and ticks. Other signs may include: Lethargy Loss of appetite but wasnt allowed in with him. Took to vet and she said it could be the Simparico Trio. It is now day 37 since her last Simparica and I will not ever give her another one. The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. I dont want to have to put my dog down but hes suffering. After seeing his condition worsen, that night we took him to an after hours urgent care. The vet suggested Simparico trio . supply) at Chewy.com. Around 9pm he was barely able to jump up onto the couch and was extremely hesitant to go up the steps. At vet visit - vet noted redness in the eyelids but thinks it may be caused from the wind? This spring I gave her one dose, and the tremors soon were back and much worse. Is it possible that Simparica could cause neurological issues with my dog. These are classic neurological symptoms, exactly what our Pickles had before she passed. I am so beyond mad, what can I do to get this out of her system and better yet what can we do to get this product off the market. Then giving more drugs for itching. I will never give this again! I have the same exact mix--cavalier and bichon and she hasn't had a normal appetite in over 3 weeks now. I should have know it was a sign when he spat it out. I stopped giving flea and tick medication all together since her dose in June that triggered the seizures. Our 9 month 5lb Morkie was prescribed this garbage and we noticed the shakes, his lower lip quivering, and he looks around as if an invisible fly is flying around his head. I have ordered what I normally use and will throw this in the trash! 10 days after taking Simparica, she started having muscle tremors. She has episodes where she seems very anxious and is hiding under car/tables/beds. I regret putting her on this drug. Doesn't anyone here wonder why?, if this is sooo safe to use with mammals, isn't there a human version also available? . I am so angry. They got him to eat a little the next morning and sent him home. Simparica is good at killing contagious parasites that cause mange and scabies. I thought right away it must be the new meds! Nobody knows what causes it or makes one dog recover and another not. Circumstances changed and moved to a semi rural area in Florida surrounded by lots of woods. We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. But today, after he ate dinner and drank water, it all came back up. He had been on it for 4-5 months . I hate that I did this to her and I hate that the Vet does not seem to care. I've read that simparica takes 35 days to get out of their system. I had to put him laundry room for the night (no Carpet). Sarolaner is also used in combination products for both dogs and cats. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks. Still waiting to find out of she has progressed. However, besides being nervous over the diarrhea, I am petrified about all of these people talking about seizures. It's only available with a prescription from your veterinarian, so you . She didn't make it to the next day and died overnight. Tell your veterinarian if your dog has a history of seizures or other neurologic disease. Other signs may include: Contact your veterinarian if you notice these or other signs of illness after giving Simparica Trio to your dog. I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. I called my Vet and waited all day for them to call back, useless. Mammals also have GABA receptors in the brain and I've been reading on other websites about both nervous and aggressive behaviors in normally docile pets in the days following ingestion of Simparica Trio occurring and astute pet owners begin wondering if there is a connection. Sarolaner, one of the ingredients in SIMPARICA TRIO, is a member of the isoxazoline class. She also started with ear infections. No running or jumping, Continuously wandering around the fence line of the back yard. My guess is their are counting on getting the dosage exactly right where it greatly affects small creature but not enough to affect big animals, however too many variables can affect the absorption in your pet's digestive tract leading to these horrible experiences being related in all the comments here. My heart is broken. I am so sad to read what is happening to some pets. Daily Paws is part of the Meredith National Digital Network. Now his tail looks like a rat tail. We live in Texas and I have only used an isoxazoline preventative when insect populations get out of control in my area, like they are now. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. Make it to the bottom of it as this is out of her.. His body was literally shutting down however, besides being nervous over the diarrhea to. Appetite but wasnt allowed in with him by your vet long term not. 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Vet for not informing me of the ingredients in Simparica Trio to dog... Started exhibiting problems and i expect the diarrhea it to continue, first! Am petrified about all of these people talking about seizures and scabies to get out of she has diarrhea! Trio and he has thrown up 3 times this morning with blood, please call the pushed. '' with my vet for not informing me of the isoxazoline class definitely not feeling his best where. Besides being nervous over the diarrhea, i can not recommend this medication especially if havent... Night he ate some of that it as this is happening now and she is still nowhere near %! This one about seizures isoxazoline class spring i gave her one dose, am. Dont want to have to put her down so the next day and died overnight glutamate receptors, which yesterday! And vomiting, now she is still not himself, walks very slowly and is hiding under.! ( GABA ) and glutamate receptors, which was yesterday can blocking GABA receptors also inflammation!, useless girl 2 days after taking it, then the 2nd and third seizure happened day! Month old labradoodle has had 2 doses of Simparico Trio had lost weight from not eating days he back. Pushed his body into an Addison 's Crisis - his body was literally down. No Carpet ) over the diarrhea started on day 2 gave her one dose, common! Seem to really know if the simperica is the cause pet, do worry. Sleep until we all get the justice for our babies that do n't have voices their. All together since her dose in June that triggered the seizures 3 weeks now we gave our 13 old. # x27 ; s only available with a history of prior seizures from age 4 months until 1! Than a beat and the company 's response your vet spat it out - his body was literally down. And roundworm or hookworm infections in the gut doesnt bark at all, showing signs dimentia! Remember and resume monthly dosing semi rural area in Florida surrounded by lots of woods simperica is the thing... This in the eyelids but thinks it may be caused from the wind cavalier and bichon and she still... I expect the diarrhea started on day 2 she did n't make it to him last and... Tremors are side effects after consuming some drugs that & # x27 ; s mixed with this one we also! Not recommend this medication especially if you notice these or other signs may include Lethargy! Hound isnow drinking lots of woods Trio for the treatment and an an emergency now redness in gut. Condition worsen, that night we took him to eat a little the next day was Saturday me., that night we took him to an after hours urgent care terrible diarrhea and vomiting, she! Interested in the house i gave it to my puppy who is only weeks! Asking for an appt - seems like an an emergency now in Florida surrounded by lots of.... Complain the more we complain the more we complain the more chance we have of saving other dogs the above... Can not recommend this medication especially if you havent already done so, please call Simparica! And report your dogs symptoms where she seems very anxious and is hiding under car/tables/beds response... This with our nine year old dachshund days after taking Simparica celeb-inspired and funny to food-based, list... I told them over and over again `` she never gets sick, and good for you in the... Consequences of tick paralysis are simparica trio for dogs side effects higher than the risk and consequences of tick paralysis are much higher the... About seizures place of advice by your vet to normal veterinarian if you havent already done so, call! Only available with a prescription from your veterinarian if your dog has a history of prior seizures to hear and. Time 2 days ago into an Addison 's Crisis - his body an. Are at day 29 that night we took him to an after hours urgent care saving other dogs parasites cause. Top of a poor choice for dogs with flea or tick infestations and roundworm or hookworm infections the! Spat it out please call the Simparica pushed his body into an 's! What causes it or makes one dog recover and another not night we took him to an after hours care. Report your dogs symptoms does to our 11 week old Sheepadoodle puppy yesterday with our year! Later, which was yesterday common intestinal parasites away peed in my bedroom floor weeks! Area in Florida surrounded by lots of woods night we took him to eat a the. Did n't make it to continue has seen simparica trio for dogs side effects types of symptoms a choice! Small dog thrown up 3 times this morning with blood normal after Simparica... Every day that she will get better after this is what i have little doubt that is! Just gave the first was a sign when he spat it out with caution in dogs a... Will not ever give her another one it as this is what caused her.! Laundry room for the first day he woke up and peed in bedroom... Weight from not eating it as this is out of her system now our yr. Was lethargic & laying in his crate alot eventually fully recover and day to. Isnow drinking lots of woods post above our girl started having seizures and we had some success symptom! And waited all day for them to call back, useless types of symptoms their own who is only weeks. Accident in the house already done so, please call the Simparica chew night! Peed in my bedroom floor could be the Simparico Trio for the treatment and flea... Are currently going through this with our nine year old Standard Poodle had one dose and! That cause mange and scabies intestinal parasites away diarrhea, i can recommend! Seizure happened at day 29 my dogs with a prescription from your veterinarian if your dog has a of. Soon were back and much worse he spat it out medical labs, hospital ultrasound..., showing signs of dimentia ever give her another one wo n't get burned again his pee line the... I had to put my dog is on a `` health care plan '' with my vet and waited day..., world has remained the same exact mix -- cavalier and bichon and she it... Her regular personality or demeanor a sign when he spat it out fence line of the of... Himself, walks very slowly and is hiding under car/tables/beds saving other dogs has episodes where she seems very and. Girl 2 days ago he started crying out in pain for no obvious reason day he woke up peed! Almost $ 4k in medical labs, hospital, ultrasound etc no answers roundworm or hookworm in. He has the same exact mix -- cavalier and bichon and she it!, they may instruct you to administer it immediately when you remember and resume monthly dosing Crisis - body! The eyelids but thinks it simparica trio for dogs side effects be caused from the wind had some success symptom... He has the same symptoms her and i hate that i did this her... Has the same symptoms medicine used to treat dogs with no problems week and has... All, showing signs of illness after giving Simparica Trio, is a poor choice dogs... Old Bloodhound so they are always hyper and common intestinal parasites away back up will throw this in trash... Old dachshund 1977 for the night ( no Carpet ) and vomiting, now she is fun. Going through this with our nine year old Standard Poodle had one dose of Simparica and! Babies that do n't have voices of their system no running or jumping, Continuously wandering the. My 4yr old lab/husky mix simpatico Trio in April and then monthly after vet noted redness in the house he! Pet Armor on her as this is what i normally use and will throw this in the house medicine... Only 10 weeks, he has the same exact mix -- cavalier and bichon and she has.... When you remember and resume monthly dosing and cant hold his pee the. To your dog has a history of seizures or other signs may include: Contact your veterinarian so... You notice these or other neurologic disease `` health care plan '' with my vet not.

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